Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
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چکیده
منابع مشابه
Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis
The incidence of rheumatoid arthritis (RA) has been reported to be correlated with a disorder of immunregulation. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play an important role in regulating the local immune microenvironment. However, the potential mechanism of RA-FLS in regulating the immnue response is not clearly understood. In this study, we demonstrated that the express...
متن کاملFibroblast-like synoviocytes: key effector cells in rheumatoid arthritis.
Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages. Fibroblast-like synoviocytes (FLS) in the synovial intimal lining also play a key role by producing cytokines that perpetuate inflammation and proteases that contribute to cartila...
متن کاملCorrection: Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis
[This corrects the article DOI: 10.18632/oncotarget.14331.].
متن کاملHypericin-photodynamic therapy inhibits proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A
Objective(s): To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A cell-line. Materials and Methods: MH7A cells were subjected to HYP-PDT intervention and apoptosis was evaluated via MTT, nuclear staining, and flowcytometry analyses. Intracellular reactive oxygen spec...
متن کاملChemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis
INTRODUCTION Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the expression of chemerin and ChemR23 in the synovium of rheumatoid arthritis (RA) patients and the stimulatory effects of chemerin on fibroblast-like synoviocytes (FLSs) from RA patients. METHODS Chemerin and ChemR23 express...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2020
ISSN: 1388-0209,1744-5116
DOI: 10.1080/13880209.2020.1711783